… Some putative mechanisms implicated in the induction and expansion of Th1 cells in the gut
… Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative …

… Figure 1 Some putative mechanisms implicated in the induction and expansion of Th1 cells
… Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response. Gut…

… This will be of great importance to delineate the specific contributions of these cells to … levels
of Th1 cytokines such as interferon γ (IFNγ) and interleukin 12 (IL12) in Crohn’s disease and …

… IL-12 is essentially implicated in disease pathogenesis even … the p40 antibody strategy in
Crohn's disease. SZ declares, … Interleukin 12 signaling in T helper type 1 (Th1) cells involves …

… of specific cytokines in disease pathogenesis. Previously, the … the importance of IL-12/IL-23
in chronic inflammatory disorders … Crohn's disease is a form of inflammatory bowel disease …

… diseases associated with pathologic Th1 responses, such as multiple sclerosis or Crohn's
disease… indicated that IL-12 plays an essential role in disease pathogenesis in this model (150…

… twelfth to be described in 1989 was Interleukin-12 (IL-12). In … The pathogenetic relevance of
such immune cell homing has … Crohn's disease LP cells manifest increased secretion of IFN-…

… is implicated in the pathogenesis of both Crohn’s disease … use in the treatment of inflammatory
conditions where a Th1 … 1997) Interleukin-12 is expressed and actively released by Crohn’…

… They both belong to the interleukin 12 family and are related … +IL23R + T cells that produce
Th1 and Th17 cytokines. Citation… Slowly, we begin to understand the complex pathogenesis, …

… increased Th1 cytokine expression is driven by interleukin-12 (IL-… Moreover, the importance
of IL-1β in the pathogenesis of CD … Th1-type T cells, are important in the pathogenesis of CD. …